LIM domain proteins in cell mechanobiology. Issue 6 (10th June 2021)

• Record Type: Journal Article
• Authors: Anderson, Caitlin A.; Kovar, David R.; Gardel, Margaret L.; Winkelman, Jonathan D.
• Is Part Of: Cytoskeleton. Volume 78:Issue 6(2021)
• Page Start: 303
• Page End: 311
• Publication Date: 2021-06-10
• Subjects: actin cytoskeleton -- focal adhesions -- LIM proteins -- adherens junctions; Cytoskeleton -- Periodicals; 571.65405
• DOI: 10.1002/cm.21677
• Languages: English
• ISSNs: 1949-3584

Abstract

Abstract: The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (L in‐11, I sl1, M EC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.