LIM domain proteins in cell mechanobiology. Issue 6 (10th June 2021) - Anderson, Caitlin A.
Abstract: The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (L in‐11, I sl1, M EC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.