The Beneficial Effects of Lippia Citriodora Extract on Diet‐Induced Obesity in Mice Are Associated with Modulation in the Gut Microbiota Composition. Issue 13 (2nd June 2020)

• Record Type: Journal Article
• Authors: Diez‐Echave, Patricia; Vezza, Teresa; Rodríguez‐Nogales, Alba; Hidalgo‐Garcia, Laura; Garrido‐Mesa, José; Ruiz‐Malagon, Antonio; Molina‐Tijeras, Jose Alberto; Romero, Miguel; Robles‐Vera, Iñaki; Leyva‐Jiménez, Francisco Javier; Lozano‐Sanchez, Jesús; Arráez‐Román, David; Segura‐Carretero, Antonio; Micol, Vicente; García, Federico; Morón, Rocío; Duarte, Juan; Rodríguez‐Cabezas, Maria Elena; Gálvez, Julio
• Is Part Of: Molecular nutrition & food research. Volume 64:Issue 13(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-02
• Subjects: diet‐induced obesity -- glucose -- lipid metabolism -- Lippia citriodora extract -- microbiota; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.202000005
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: Obesity is characterized by a dysfunction in the adipose tissue and an inflammatory subclinical state leading to insulin resistance and increased risk of cardiovascular diseases. It is also associated with intestinal dysbiosis that contributes to inflammation development. Lippia citriodora (LCE) contains high levels of polyphenolpropanoids and has shown promising results in obesity. The aim of this study is to investigate a well‐characterized extract of LCE in a model of metabolic syndrome in mice, focusing on its effects on metabolic tissues, endothelial dysfunction, and microbiome. Methods: Mice are fed a high fat diet (HFD) for six weeks and treated daily with LCE (1, 10, and 25 mg kg −1 ). Glucose and lipid metabolism is investigated. The inflammatory state in the metabolic tissues and the intestinal microbiota composition are characterized, as well as the endothelium‐dependent vasodilator response to acetylcholine. Results: LCE reduces fat accumulation and improves plasma glycemic and lipid profiles, as well as the inflammatory process and vascular dysfunction. Moreover, LCE lessens intestinal dysbiosis, as it reduces the Firmicutes / Bacteroidetes ratio and increases Akkermansia abundance in comparison with untreated HFD mice. Conclusion: The antiobesity therapeutic properties of LCE are most probably mediated by the synergic effects of its bioactive compounds. Abstract : The aim of this study is the evaluation of Lippia Citriodora extract (LCE) treatment on diet‐induced obesity in mice. LCE administration ameliorates induced obesity, enhancing the inflammatory status and the vascular functionality. Furthermore, it is the first time that LCE treatment is shown to modulate the gut microbiota. These findings support the use of LCE as a new functional food in metabolic syndrome.