Recent advances on bioactive food derived anti-diabetic hydrolysates and peptides from natural resources. (November 2021)

• Record Type: Journal Article
• Authors: Elam, Elnur; Feng, Jun; Lv, Yan-Mei; Ni, Zhi-Jing; Sun, Ping; Thakur, Kiran; Zhang, Jian-Guo; Ma, Yi-Long; Wei, Zhao-Jun
• Is Part Of: Journal of functional foods. Volume 86(2021)
• Publication Date: 2021-11
• Subjects: Food derived peptides -- Functional food -- Nutrition -- Anti-diabetic -- Natural resources; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2021.104674
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: An overview of advances on antidiabetic hydrolysates and peptides in highlighted. This review emphasizes on proteins with a particular focus on anti-diabetic inhibitory peptides. Modes of inhibition and structure–activity relationship of peptide inhibitors are discussed. To elicit systemic effects, assess the efficacy and sufficient absorption are the key factor. Adopting novel industrial strategies can bridge the gap between analysis and appraisal of sensory attributes. Abstract: In recent years, burgeoning reports have emphasized that food-derived peptides and protein hydrolysates can confer additional health benefits beyond nutritional role. The biologically active peptides are regarded as nutraceuticals and functional food ingredients displaying antihypertensive, antioxidant, mineral binding, maintenance of intestinal barrier function, and antimicrobial attributes. The food-derived bioactive peptides serve as an alternative to pharmacological treatments in the control of hypertension, the management of type 2 diabetes (T2D), and oxidative stress. This review integrates the existing information on plant and animal proteins with a particular focus on anti-diabetic inhibitory peptides. Besides, their modes of inhibition and structure–activity relationship of peptide inhibitors are also discussed. To elicit systemic effects, efficacy assessment and sufficient absorption are the key factors which have been proved by in vitro and in vivo studies, particularly if health-related claims are to be made.