PP.16 Pregnancy Outcomes in Women with Known Sickle Cell Disease: A Case Control Study from a Dedicated Tertiary Joint Obstetric Sickle Cell Clinic. (26th April 2013)

• Record Type: Journal Article
• Authors: Nanda, S; Robinson, S; Sankaran, S; Kyle, P; Nicolaides, K; Oteng-ntim, E; Weaver, A
• Is Part Of: Archives of disease in childhood. Volume 98(2013)Supplement 1
• Page Start: A86
• Page End: A86
• Publication Date: 2013-04-26
• Subjects: Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/archdischild-2013-303966.297
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Introduction: Sickle cell disease (SCD) in pregnancy has been associated with adverse pregnancy outcomes. However, with a multidisciplinary approach and surveillance, there is a suggestion of improvement in the overall outcome. The aim of this study was to evaluate the pregnancy outcomes in women with known SCD in a singleton pregnancy seen in our clinic, and to assess whether the presence of SCD alters the maternal serum analytes (Free B-human chorionic gonadotrophin and Pregnancy-associated plasma protein - A) at combined screening. Methods: Case-control study of all pregnant women with SCD undergoing combined screening from 01/01/2008 to 31/12/2011. Each case was matched with 3 non-SCD controls. Pregnancy outcomes in the two groups were compared. Conclusion: Women with SCD, when followed closely from the first trimester, have successful pregnancy outcomes. However, our data suggests an increased incidence of pre-eclampsia and lower birth weights compared to non-SCD controls. There was also a significant difference noted in the maternal serum analytes. Larger prospective studies are therefore required to assess the impact of SCD on combined screening.