PP.16 Pregnancy Outcomes in Women with Known Sickle Cell Disease: A Case Control Study from a Dedicated Tertiary Joint Obstetric Sickle Cell Clinic. (26th April 2013) - Nanda, S
Abstract : Introduction: Sickle cell disease (SCD) in pregnancy has been associated with adverse pregnancy outcomes. However, with a multidisciplinary approach and surveillance, there is a suggestion of improvement in the overall outcome. The aim of this study was to evaluate the pregnancy outcomes in women with known SCD in a singleton pregnancy seen in our clinic, and to assess whether the presence of SCD alters the maternal serum analytes (Free B-human chorionic gonadotrophin and Pregnancy-associated plasma protein - A) at combined screening. Methods: Case-control study of all pregnant women with SCD undergoing combined screening from 01/01/2008 to 31/12/2011. Each case was matched with 3 non-SCD controls. Pregnancy outcomes in the two groups were compared. Conclusion: Women with SCD, when followed closely from the first trimester, have successful pregnancy outcomes. However, our data suggests an increased incidence of pre-eclampsia and lower birth weights compared to non-SCD controls. There was also a significant difference noted in the maternal serum analytes. Larger prospective studies are therefore required to assess the impact of SCD on combined screening.