Age‐related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis). Issue 5 (6th August 2021)

• Record Type: Journal Article
• Authors: Darusman, Huda Shalahudin; Li Wern, Tan; Sajuthi, Dondin; Schapiro, Steven J.; Hau, Jann
• Is Part Of: Journal of medical primatology. Volume 50:Issue 5(2021)
• Page Start: 270
• Page End: 272
• Publication Date: 2021-08-06
• Subjects: aging -- animal model -- cognitive -- non‐human primates -- sex hormone; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12536
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: Aged memory‐impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ42 ) and serum testosterone compared with young animals and non–memory‐impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging‐associated senile dementia of the Alzheimer type.