Age‐related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis). Issue 5 (6th August 2021) - Darusman, Huda Shalahudin
Abstract: Aged memory‐impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ42 ) and serum testosterone compared with young animals and non–memory‐impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging‐associated senile dementia of the Alzheimer type.