Curcumin induced G2/M cycle arrest in SK‐N‐SH neuroblastoma cells through the ROS‐mediated p53 signaling pathway. Issue 9 (31st July 2021)

• Record Type: Journal Article
• Authors: Ye, Zijie; Chen, Danyang; Zheng, Ruilin; Chen, Haiyang; Xu, Tiantian; Wang, Changbing; Zhu, Shibo; Gao, Xiaofeng; Zhang, Jin; Li, Dian; Pang, Yueyin; Zhu, Bing; Li, Yinghua; Jia, Wei
• Is Part Of: Journal of food biochemistry. Volume 45:Issue 9(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-31
• Subjects: apoptosis -- curcumin -- neuroblastoma -- reactive oxygen species; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Biochemistry -- Periodicals; 664.024
• DOI: 10.1111/jfbc.13888
• Languages: English
• ISSNs: 0145-8884

Abstract

Abstract: Neuroblastoma (NB) is a solid tumor in the nervous system and has a high mortality rate in children. Curcumin has well‐characterized anticancer properties, while there is no effective method in clinical treatment. MTT assays revealed that curcumin dramatically inhibited the proliferation of SK‐N‐SH cells. Compared with the control group, curcumin markedly restrained the migration of SK‐N‐SH cells. Curcumin induced SK‐N‐SH cell apoptosis by G2/M cycle arrest and activated caspase‐3 activity. Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl‐2 signal pathways. This finding demonstrated the application of curcumin is an effective strategy for the therapeutics of NB Abstract : Neuroblastoma (NB) is a solid tumor in the nervous system and has a high mortality rate in children. Curcumin induced SK‐N‐SH cell apoptosis by G2/M cycle arrest and promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl‐2 signal pathways. This finding demonstrated the application of curcumin is an effective strategy for the therapeutics of NB.