Comprehensive Human Milk Patterns Are Related to Infant Growth and Allergy in the CHMP Study. Issue 17 (14th July 2021)

• Record Type: Journal Article
• Authors: Jiang, Shilong; Pan, Jiancun; Li, Yuanyuan; Ju, Mengnan; Zhang, Wei; Lu, Jing; Lv, Jiaping; Li, Kaifeng
• Is Part Of: Molecular nutrition & food research. Volume 65:Issue 17(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-14
• Subjects: glycome -- human milk patterns -- lipidome -- proteome -- the Chinese Human Milk Project; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.202100011
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: The aim of the present study is to identify human milk pattern using multi‐omics datasets and to explore association between patterns, infant growth, and allergy using data from the Chinese Human Milk Project (CHMP) study. Methods and Results: Three patterns are identified from integrative analysis of proteome, lipidome, and glycome profiles of 143 mature human milk samples. Factor 1 is positively associated with 128 proteins, phospholipids, and human milk oligosaccharides (HMOs) including lacto N‐neohexaose (LNnH) and lacto‐N‐difucohexaose II (LNDFH II); factor 2 is negatively associated with as1 ‐casein, phospholipids while positively associates with HMOs including LNnH, lactosialyl tetrasaccharide c (LSTc), and 2'‐fucosyllactose (2'FL); factor 3 is positively associated with lysophospholipids while negatively associates with 27 proteins, triglycerides with two saturated fatty acids, 6'‐sialyllactose (6'SL) and 2'FL. In general, factor 1 and factor 2 are associated with slower while factor 3 is associated with faster growth rate ( p < 0.044). One unit higher in loadings of factor 2 is associated with 34% lower risk of allergies ( p ≤ 0.017). Associations are not significant after adjustment for city except for factor 1. Conclusions: Three possible human milk patterns with varying degree of stability are identified. Future work is needed to understand these patterns in terms of generalization, biologic mechanisms, and genotype influences. Abstract : Three possible human milk patterns are derived from proteome, lipidome, and glycome profiles of 143 human milk samples of Chinese mothers. The present study clearly shows that human milk patterns are related to heterogenous growth pattern and risk of allergy of the infants. Future studies are needed to replicate our results.