Diagnostic value of blood thiamine metabolites in Alzheimer's disease examined by 11C-PiB PET scanning. (23rd February 2017)

• Record Type: Journal Article
• Authors: Chen, Zhichun; Pan, Xiaoli; Fei, Guoqiang; Pan, Shumei; Bao, Weiqi; Ren, Shuhua; Guan, Yihui; Zhong, Chunjiu
• Is Part Of: Future science OA. Volume 3:Number 2(2017)
• Publication Date: 2017-02-23
• Subjects: Alzheimer's disease -- blood biomarker -- diagnosis -- PiB positive -- PiB negative -- positron emission tomography with 11C-Pittsburgh compound B -- thiamine -- thiamine diphosphate -- thiamine metabolites -- γ-value; Medicine -- Periodicals; Biotechnology -- Periodicals; 610
• DOI: 10.4155/fsoa-2016-0087
• Languages: English
• ISSNs: 2056-5623

Abstract

Aim: We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with 11 C-Pittsburgh compound B ( 11 C-PiB PET) scanning.Methods: Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received 11 C-PiB PET scanning for the measurement of cerebral amyloid deposition.Results: Thiamine diphosphate (TDP) had 66.7% sensitivity and 80.0% specificity for AD diagnosis, while the γ-value representing the best combination of thiamine metabolites and age had 24.2% sensitivity and 100.0% specificity according to the cut-off value of our previous study.Conclusion: Blood TDP but not γ-value exhibited results significant for AD diagnosis. Lay abstract: In this study, we investigated the diagnostic value of blood thiamine metabolites for Alzheimer's disease as examined by positron emission tomography with 11 C-Pittsburgh compound B scanning. Our results suggest that the reduction of blood thiamine diphosphate may be a stable biomarker useful for Alzheimer's disease diagnosis.