Diagnostic value of blood thiamine metabolites in Alzheimer's disease examined by 11C-PiB PET scanning. (23rd February 2017) - Chen, Zhichun
Aim: We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with 11 C-Pittsburgh compound B ( 11 C-PiB PET) scanning.Methods: Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received 11 C-PiB PET scanning for the measurement of cerebral amyloid deposition.Results: Thiamine diphosphate (TDP) had 66.7% sensitivity and 80.0% specificity for AD diagnosis, while the γ-value representing the best combination of thiamine metabolites and age had 24.2% sensitivity and 100.0% specificity according to the cut-off value of our previous study.Conclusion: Blood TDP but not γ-value exhibited results significant for AD diagnosis. Lay abstract: In this study, we investigated the diagnostic value of blood thiamine metabolites for Alzheimer's disease as examined by positron emission tomography with 11 C-Pittsburgh compound B scanning. Our results suggest that the reduction of blood thiamine diphosphate may be a stable biomarker useful for Alzheimer's disease diagnosis.