Anti‐hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats. (21st March 2021)

• Record Type: Journal Article
• Authors: Qi, Xiaofen; Chen, Haoran; Guan, Kaifang; Wang, Rongchun; Ma, Ying
• Is Part Of: Journal of the science of food and agriculture. Volume 101:Number 12(2021)
• Page Start: 4916
• Page End: 4924
• Publication Date: 2021-03-21
• Subjects: hyperuricemia -- whey protein hydrolysate -- uric acid -- xanthine oxidase -- organic ion transporters -- renal dysfunction; Food -- Periodicals; Agriculture -- Periodicals; 664
• DOI: 10.1002/jsfa.11135
• Languages: English
• ISSNs: 0022-5142

Abstract

Abstract: BACKGROUND: Hyperuricemia (HUA) is a serious public health concern globally that needs to be solved. It is closely related to gout and other metabolic diseases. To develop a safe and effective dietary supplementation for alleviating HUA, we investigated the effects of whey protein hydrolysate (WPH) on HUA and associated renal dysfunction and explored their underlying mechanism. RESULTS: Potassium oxonate was used to induce HUA in model rats, who were then administered WPH for 21 days. The results showed that WPH significantly inhibited xanthine oxidase and adenosine deaminase activity in serum and liver, decreased uric acid (UA), creatinine, and blood urea nitrogen levels in serum, and increased the UA excretion in urine. In addition, WPH downregulated the expression of urate transporter 1 and upregulated the expression of organic anion transporter 1, adenosine triphosphate binding cassette subfamily G member 2, organic cation/carnitine transporters 1 and 2, and organic cation transporter 1 in kidneys. CONCLUSION: These findings demonstrated for the first time that WPH could alleviate HUA by inhibiting UA production and promoting UA excretion, and improve the renal dysfunction caused by HUA. Thus, WPH may be a potential functional ingredient for the prevention and treatment of HUA and associated renal dysfunction. © 2021 Society of Chemical Industry