Formulation and evaluation of a α-linolenic acid and vitamin E succinate microemulsion with low surfactant content and free of co-surfactant for use as a nutritional supplement. (1st December 2021)

• Record Type: Journal Article
• Authors: Ye, Dan; Shen, Liyan; Sun, Ying; Zhang, Di; Tan, Xiao; Jing, Panpan; Zhang, Min; Tian, Qingping
• Is Part Of: Food chemistry. Volume 364(2021)
• Publication Date: 2021-12-01
• Subjects: α-Linolenic acid -- Vitamin E succinate -- Co-surfactant free microemulsion -- Stability -- Release ability; Vitamin E succinate (PubChem CID: 20353) -- α-Linolenic acid (PubChem CID: 5280934) -- Vitamin E acetate (PubChem CID: 86472) -- d-α-Tocopherol polyethylene glycol 1000 succinate (PubChem CID: 71406) -- Stearyl glycyrrhetinate (PubChem CID: 10700068).; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2021.130433
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: A free-alcohol and low surfactant α-linolenic acid (ALA) microemulsion was designed. Vitamin E succinate (VES) can significantly improve the ALA microemulsion regions. ALA microemulsion was stable to resist temperature, salt ion, pH and oxidation. ALA microemulsion can facilitate the release and hydrolysis VES in vitro assessment. Abstract: Herein, we have designed an alcohol-free and low-surfactant microemulsion to safely and effectively supply α-linolenic acid (ALA) and vitamin E (VE). Ternary phase diagrams show that the use of medium- or short-chain alcohols as the co-surfactant (CoS) was unfavorable for the formation of the ALA microemulsion due to the competitive hydrogen bonding effect and vitamin E succinate (VES) significantly increased the ALA microemulsion region by improving the hydrophilicity of the oil phase. The optimal microemulsion formulation (Mav ) was 6.86% ALA, 1.14% VES, 12% surfactant and 80% water, with uniformly dispersed spherical particles with diameters of ~ 25.41 nm and viscosity of 35.17 mPa·s. The Mav was stable to high temperature, ionic strength and pH, and exhibited good physical and anti-oxidation stability. The Mav facilitated the release and hydrolysis of VES, indicating that the CoS-free microemulsion with low surfactant content is promising for the safe and effective supply of ALA and VE.