269 Prevention of hypertensive injury to the brain by intensive treatment in intracerebral haemorrhage (PROHIBIT-ICH): protocol for a randomised controlled trial of telemetric home BP monitoring. Issue 12 (14th November 2019)

• Record Type: Journal Article
• Authors: McGurgan, Iain; Butt, Shahena; Silver, Louise; Werring, David; Rothwell, Peter
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 90:Issue 12(2019)
• Page Start: e63
• Page End: e64
• Publication Date: 2019-11-14
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2019-ABN-2.214
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Background: Intracerebral haemorrhage (ICH) accounts for about 10% of strokes in the UK and is a major cause of severe disability and death. Sustained post-acute blood pressure (BP) management arguably holds the most potential to improve long-term prognosis, but there have been no trials to guide the optimal strategy for BP lowering after ICH. Telemetric home BP monitoring is a promising intervention to improve control. Methods: 112 adult survivors of hypertension-related ICH across multiple UK sites will be randomised to intensive telemetric home BP monitoring-guided treatment (intervention) to achieve a target of <120/80 mmHg or standard care (control). Outcomes: Efficacy: the magnitude of difference in BP at 3 months in the intervention arm versus the control arm compared with baseline measures Feasibility: consent rate; dropout rate from the intervention prior to 1 month; patient approval of the monitoring process Safety: serious adverse events related to reducing BP in the intervention arm Conclusion: The BP monitoring component of PROHIBIT-ICH will determine whether a strategy of intensive BP treatment guided by telemetric monitoring for an extended period of time after spontaneous ICH is feasible, safe and effective in reducing BP.