269 Prevention of hypertensive injury to the brain by intensive treatment in intracerebral haemorrhage (PROHIBIT-ICH): protocol for a randomised controlled trial of telemetric home BP monitoring. Issue 12 (14th November 2019) - McGurgan, Iain
Abstract : Background: Intracerebral haemorrhage (ICH) accounts for about 10% of strokes in the UK and is a major cause of severe disability and death. Sustained post-acute blood pressure (BP) management arguably holds the most potential to improve long-term prognosis, but there have been no trials to guide the optimal strategy for BP lowering after ICH. Telemetric home BP monitoring is a promising intervention to improve control. Methods: 112 adult survivors of hypertension-related ICH across multiple UK sites will be randomised to intensive telemetric home BP monitoring-guided treatment (intervention) to achieve a target of <120/80 mmHg or standard care (control). Outcomes: Efficacy: the magnitude of difference in BP at 3 months in the intervention arm versus the control arm compared with baseline measures Feasibility: consent rate; dropout rate from the intervention prior to 1 month; patient approval of the monitoring process Safety: serious adverse events related to reducing BP in the intervention arm Conclusion: The BP monitoring component of PROHIBIT-ICH will determine whether a strategy of intensive BP treatment guided by telemetric monitoring for an extended period of time after spontaneous ICH is feasible, safe and effective in reducing BP.