Construction of carboxymethyl konjac glucomannan/chitosan complex nanogels as potential delivery vehicles for curcumin. (15th November 2021)

• Record Type: Journal Article
• Authors: Wu, Chunhua; Sun, Jishuai; Jiang, Haixin; Li, Yuanzhao; Pang, Jie
• Is Part Of: Food chemistry. Volume 362(2021)
• Publication Date: 2021-11-15
• Subjects: Nanogels -- Carboxymethyl konjac glucomannan -- Chitosan -- Curcumin -- EDC/NHS-initiated crosslinking -- Controlled release; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2021.130242
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Highlights: Carboxymethyl konjac glucomannan/chitosan nanogels were successfully prepared. The EDC/NHS crosslinking did not significantly alter the morphology of the nanogels. The crosslinked nanogels exhibited good sustained release behavior in simulated GT. Crosslinked nanogels presented promising features as oral delivery vehicles. Abstract: Construction of nanoscale delivery systems from natural food biopolymer complexes have attracted increasing interests in the fields of food industries. In this study, novel carboxymethyl konjac glucomannan/ chitosan (CMKGM/CS) nanogels with and without 1-ethyl-3-(3-dimethylaminopropyl) / N -hydroxysuccinimide) (EDC/NHS)-initiated crosslinking were prepared. The physicochemical and structural properties of the CMKGM/CS nanogels and their potential to be a delivery vehicle for curcumin were investigated. Compared to original uncrosslinked nanogels, crosslinking did not alter particle size and morphology but decreased zeta potential of nanogels. Fourier transform infrared spectrum confirmed that the amide linkage was formed between CMKGM and CS, which obviously enhanced the stability of crosslinked nanogels under gastrointestinal conditions. Furthermore, the crosslinked nanogels not only had higher encapsulation efficiency of curcumin but also better sustained release behavior under simulated gastrointestinal conditions. These findings suggested that the crosslinked CMKGM/CS nanogels might be a promising delivery system for nutrients.