Α‐Alkylation of Ketones with Secondary Alcohols Catalyzed by Well‐Defined Cp*CoIII‐Complexes. Issue 15 (26th June 2019)

• Record Type: Journal Article
• Authors: Chakraborty, Priyanka; Gangwar, Manoj Kumar; Emayavaramban, Balakumar; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker
• Is Part Of: ChemSusChem. Volume 12:Issue 15(2019)
• Page Start: 3463
• Page End: 3467
• Publication Date: 2019-06-26
• Subjects: alkylation -- cobalt -- ketones -- secondary alcohols -- α-alkylation; Green chemistry -- Periodicals; Sustainable engineering -- Periodicals; Chemistry -- Periodicals; Chemical engineering -- Periodicals; 660
• DOI: 10.1002/cssc.201900990
• Languages: English
• ISSNs: 1864-5631

Abstract

Abstract: Although α‐alkylation of ketones with primary alcohols by transition‐metal catalysis is well‐known, the same process with secondary alcohols is arduous and complicated by self‐condensation. Herein a well‐defined, high‐valence cobalt(III)‐catalyst was applied for successful α‐alkylation of ketones with secondary alcohols. A wide‐variety of secondary alcohols, which include cyclic, acyclic, symmetrical, and unsymmetrical compounds, was employed as alkylating agents to produce β‐alkyl aryl ketones. Abstract : Secondary success : A well‐defined, air‐stable, Co III ‐catalyzed α‐alkylation of ketones is achieved by using secondary alcohols as alkylating agents. A wide‐variety of secondary alcohols, which include cyclic, acyclic, symmetrical, and unsymmetrical compounds, is employed as alkylating agents to produce β‐alkyl aryl ketones.