Α‐Alkylation of Ketones with Secondary Alcohols Catalyzed by Well‐Defined Cp*CoIII‐Complexes. Issue 15 (26th June 2019) - Chakraborty, Priyanka
Abstract: Although α‐alkylation of ketones with primary alcohols by transition‐metal catalysis is well‐known, the same process with secondary alcohols is arduous and complicated by self‐condensation. Herein a well‐defined, high‐valence cobalt(III)‐catalyst was applied for successful α‐alkylation of ketones with secondary alcohols. A wide‐variety of secondary alcohols, which include cyclic, acyclic, symmetrical, and unsymmetrical compounds, was employed as alkylating agents to produce β‐alkyl aryl ketones. Abstract : Secondary success : A well‐defined, air‐stable, Co III ‐catalyzed α‐alkylation of ketones is achieved by using secondary alcohols as alkylating agents. A wide‐variety of secondary alcohols, which include cyclic, acyclic, symmetrical, and unsymmetrical compounds, is employed as alkylating agents to produce β‐alkyl aryl ketones.