Synthesis of alkynyl Z-ketimines and their application in amine-catalyzed asymmetric Mannich reactions and conjugate addition. (2nd July 2021)

• Record Type: Journal Article
• Authors: Homma, Chihiro; Yamanaka, Masahiro; Kano, Taichi; Maruoka, Keiji
• Is Part Of: Tetrahedron. Volume 91(2021)
• Publication Date: 2021-07-02
• Subjects: Amine catalyst -- Asymmetric reaction -- Mannich reaction -- Conjugate addition -- Ketimines; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2021.132225
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: We developed a facile and practical synthesis of various alkynyl Z -ketimines, which can be used as a synthetic equivalent of alkyl ketimines. The obtained alkynyl Z -ketimines could be successfully applied in enantioselective Mannich reaction and conjugate addition catalyzed by a chiral amine with an acid functionality. Graphical abstract: Image 1