Synthesis of alkynyl Z-ketimines and their application in amine-catalyzed asymmetric Mannich reactions and conjugate addition. (2nd July 2021) - Homma, Chihiro
Abstract: We developed a facile and practical synthesis of various alkynyl Z -ketimines, which can be used as a synthetic equivalent of alkyl ketimines. The obtained alkynyl Z -ketimines could be successfully applied in enantioselective Mannich reaction and conjugate addition catalyzed by a chiral amine with an acid functionality. Graphical abstract: Image 1