Proinflammatory Diet Increases Circulating Inflammatory Biomarkers and Falls Risk in Community-Dwelling Older Men. Issue 2 (26th October 2019)

• Record Type: Journal Article
• Authors: Cervo, Mavil May C; Scott, David; Seibel, Markus J; Cumming, Robert G; Naganathan, Vasi; Blyth, Fiona M; Le Couteur, David G; Handelsman, David J; Ribeiro, Rosilene V; Waite, Louise M; Shivappa, Nitin; Hebert, James R; Hirani, Vasant
• Is Part Of: Journal of nutrition. Volume 150:Issue 2(2020)
• Page Start: 373
• Page End: 381
• Publication Date: 2019-10-26
• Subjects: dietary inflammatory index -- chronic inflammation -- inflammatory biomarkers -- bone mineral density -- falls -- community-dwelling older men; Nutrition -- Periodicals; Diet -- Periodicals; 613.205
• DOI: 10.1093/jn/nxz256
• Languages: English
• ISSNs: 0022-3166

Abstract

ABSTRACT: Background: The relations between diet, chronic inflammation, and musculoskeletal health are unclear, especially among older men. Objective: This study aimed to determine associations of the Dietary Inflammatory Index (DII) with inflammatory biomarkers, musculoskeletal health, and falls risk in community-dwelling older men. Methods: The cross-sectional analysis included 794 community-dwelling men, mean age 81.1 ± 4.5 y, who participated in the 5-y follow-up of the Concord Health and Aging in Men Project. Of these, 616 were seen again 3 y later for the longitudinal analysis. Energy-adjusted DII (E-DII) was calculated from a validated diet history questionnaire. Bone mineral density (BMD) was measured using DXA. Twenty-four inflammatory biomarkers were analyzed. Incident falls over 3 y were determined through telephone interviews every 4 mo. Multiple regression, linear mixed effects models, negative binomial regression, and mediation analysis were utilized in this study. Results: A higher E-DII score (indicating a more proinflammatory diet) was associated with higher concentrations of IL-6 (β: 0.028 pg/mL; 95% CI: 0.003, 0.053), IL-7 (β: 0.020 pg/mL; 95% CI: 0.002, 0.037), and TNF-α (β: 0.027 pg/mL; 95% CI: 0.003, 0.051). A higher E-DII score was also associated with lower appendicular lean mass adjusted for BMI (ALMBMI ) (β: −0.006 kg/m 2 ; 95% CI: −0.010, −0.001). For every unit increase in E-DII (range: −4.91 to +3.66 units), incident falls rates increased by 13% (incidence rate ratio: 1.13; 95% CI: 1.05, 1.21) over 3 y. Mediation analysis showed that the association between E-DII and 3-y incident falls was influenced by the concentrations of IL-7 by 24%. There was no association between E-DII and BMD. Conclusions: Consumption of a proinflammatory diet was associated with increased concentrations of IL-6, IL-7, and TNF-α; increased falls risk; and lower ALMBMI in community-dwelling older men. The association between incident falls and E-DII was partly mediated by concentrations of IL-7.