Synthesis of N-Alkyl-2-thiomethyl Benzimidazoles: A Green Approach. (17th March 2014)

• Record Type: Journal Article
• Authors: Rao, S. Srinivas; Reddy, Ch. Venkata Ramana; Dubey, P. K.
• Other Names: Ogilvie William Academic Editor.
• Is Part Of: Organic chemistry international. Volume 2014(2014)
• Publication Date: 2014-03-17
• Subjects: Chemistry, Organic -- Periodicals; Chemistry, Organic; Periodicals; 547
• DOI: 10.1155/2014/239710
• Languages: English
• ISSNs: 2090-200X

Abstract

Abstract : A green approach for the synthesis of N-alkyl-2-thiomethyl benzimidazoles 2 (R=CH3, C2 H5, CH2 Ph) under different conditions has been developed from N-alkyl-2-chloromethyl benzimidazole (i.e., CH3, C2 H5, CH2 Ph) 1 by reaction with thiourea by physical grinding, or by using green solvents like ethanol and PEG-600, or by using microwave irradiation technique.