Synthesis of N-Alkyl-2-thiomethyl Benzimidazoles: A Green Approach. (17th March 2014) - Rao, S. Srinivas
Abstract : A green approach for the synthesis of N-alkyl-2-thiomethyl benzimidazoles 2 (R=CH3, C2 H5, CH2 Ph) under different conditions has been developed from N-alkyl-2-chloromethyl benzimidazole (i.e., CH3, C2 H5, CH2 Ph) 1 by reaction with thiourea by physical grinding, or by using green solvents like ethanol and PEG-600, or by using microwave irradiation technique.