Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases. Issue 5 (15th April 2021)

• Record Type: Journal Article
• Authors: Liu, Shiyu; Xiao, Pingting; Kuang, Yujia; Hao, Jinhua; Huang, Tianqing; Liu, Ehu
• Is Part Of: Journal of food biochemistry. Volume 45:Issue 5(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-04-15
• Subjects: chemical components -- flavonoids from sea buckthorn -- metabolic regulation -- pharmacokinetic studies; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Biochemistry -- Periodicals; 664.024
• DOI: 10.1111/jfbc.13724
• Languages: English
• ISSNs: 0145-8884

Abstract

Abstract: Sea buckthorn ( Hippophae rhamnoides L., SBT) is being used as a folk medicine for their diverse medicinal properties. Flavonoids are generally considered as the main bioactive and characteristic ingredients in SBT. This review was conducted using a comprehensive literature search on the chemical components, quality control, pharmacokinetics of flavonoids from SBT (FSBT). Particularly, we highlighted the therapeutic potential in metabolic diseases and clinical applications of FSBT. More than 95 flavonoids have been identified from SBT. Although the oral bioavailability of FSBT was relatively low, FSBT displays significant effect on the regulation of metabolism to ameliorate metabolic disorders and their complications. There is a heightened need to explore the bioactive compounds in SBT and mechanism(s) of action of FSBT in order to fully understand the pathways of their activities. Practical applications: For years, due to the increasing emergence of metabolic syndrome and diverse functions of FSBT in regulating metabolism, they can be efficiently utilized for human health and have an urgent need to become a hotspot for research. This review will broaden the understanding of FSBT, providing some directions for further development and expanding the therapeutic applications of FSBT. Abstract : As the main bioactive and characteristic ingredients of sea buckthorn (SBT), flavonoids play important roles in metabolic protection. There are more than 95 flavonoids identified from SBT and many analytical methods established to ensure their quality. Developing formulations and interacting multi‐component help to improve the low oral bioavailability of flavonoids from SBT.