Characterization, antioxidant, and neuroprotective effects of anthocyanins from Nitraria tangutorum Bobr. fruit. (15th August 2021)

• Record Type: Journal Article
• Authors: Chen, Shasha; Zhou, Haonan; Zhang, Gong; Dong, Qi; Wang, Zhenhua; Wang, Honglun; Hu, Na
• Is Part Of: Food chemistry. Volume 353(2021)
• Publication Date: 2021-08-15
• Subjects: Nitraria tangutorum Bobr. -- Anthocyanin -- Composition -- Antioxidant -- Neuroprotective effects; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2021.129435
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Nine anthocyanins were identified from ANF, and C3G is the most abundant (87.06%). C3G contributed the highest antioxidant capacity in the online HPLC-DPPH assay. ANF ameliorated memory deficits, Aβ level, and gliosis in d -gal-treated rats. ANF reduced ROS and MDA levels, while elevated T -SOD and GSH levels in rats. Abstract: An anthocyanin-rich extract was obtained from Nitraria tangutorum Bobr. fruit, namely ANF, and its composition, antioxidant and neuroprotective effects were studied. Nine anthocyanins were identified from the ANF using UPLC-Triple-TOF/MS analysis, and cyanidin-3-[2′'-(6′''-coumaroyl)-glucosyl]-glucoside (C3G) is the most abundant anthocyanin (87.06%). ANF exhibited high ferric reducing antioxidant power (FRAP) and ABTS radical scavenging activity. The online HPLC-DPPH screening revealed that C3G contributed the highest antioxidant capacity. ANF showed potential neuroprotective effects by relieving d -Galactose-induced memory deficits, reducing overexpression of receptor for advanced glycation end products (RAGE) and amyloid-beta42 (Aβ42) in the hippocampus of rats. Besides, ANF could inhibit oxidative stress by reducing the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in the hippocampus, while elevating amounts of total superoxide dismutase ( T -SOD) and glutathione (GSH) in the serum of rats. Thus, ANF has great potential in the development of food and health products related to antioxidant and neuroprotective effects.