Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. (June 2021)

• Record Type: Journal Article
• Authors: Kellici, Tahsin F.; Pilka, Ewa S.; Bodkin, Michael J.
• Is Part Of: Trends in pharmacological sciences. Volume 42:Number 6(2021)
• Page Start: 431
• Page End: 433
• Publication Date: 2021-06
• Subjects: Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2021.03.006
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with COVID-19-related ARDS and summarize the available data on inhibitors of this target.