Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. (June 2021) - Kellici, Tahsin F.
Abstract : Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with COVID-19-related ARDS and summarize the available data on inhibitors of this target.