G-Protein Peptidomimetics Stabilize GPCR Active State Conformations. (June 2021)

• Record Type: Journal Article
• Authors: Gumpper, Ryan H.; Roth, Bryan L.
• Is Part Of: Trends in pharmacological sciences. Volume 42:Number 6(2021)
• Page Start: 429
• Page End: 430
• Publication Date: 2021-06
• Subjects: peptidomimetics -- G protein-coupled receptors -- G proteins; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2021.03.009
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Technologies stabilizing the active state of G protein-coupled receptors (GPCRs) represent potential breakthroughs for interrogating G protein activation. Camelid nanobodies have been used as a 'one tool, one receptor' paradigm. However, the development of G protein peptidomimetics, as discussed in Mannes et al . represent the opportunity to develop generically activating probes for many GPCRs.