G-Protein Peptidomimetics Stabilize GPCR Active State Conformations. (June 2021) - Gumpper, Ryan H.
Abstract : Technologies stabilizing the active state of G protein-coupled receptors (GPCRs) represent potential breakthroughs for interrogating G protein activation. Camelid nanobodies have been used as a 'one tool, one receptor' paradigm. However, the development of G protein peptidomimetics, as discussed in Mannes et al . represent the opportunity to develop generically activating probes for many GPCRs.