Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis. Issue 12 (2nd December 2015)

• Record Type: Journal Article
• Authors: Tokuoka, Masafumi; Kikuchi, Tomoki; Shinohara, Yasutomo; Koyama, Akifumi; Iio, Shin-ichiro; Kubota, Takaaki; Kobayashi, Jun'ichi; Koyama, Yasuji; Totsuka, Akira; Shindo, Hitoshi; Sato, Kazuo
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 12(2015)
• Page Start: 2081
• Page End: 2085
• Publication Date: 2015-12-02
• Subjects: Aspergillus oryzae -- cyclopiazonic acid -- speradine A -- secondary metabolism; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2015.1065167
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of A. tamarii resulted in the speradine A production in a 2-oxoCPA producing A. oryzae strain, indicating cpaM is involved in the speradine A biosynthesis.