Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis. Issue 12 (2nd December 2015) - Tokuoka, Masafumi
Abstract: Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of A. tamarii resulted in the speradine A production in a 2-oxoCPA producing A. oryzae strain, indicating cpaM is involved in the speradine A biosynthesis.