Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake. Issue 7 (15th March 2021)

• Record Type: Journal Article
• Authors: Yi, Zhenwei; Liu, Xiaofeng; Liang, Lihong; Wang, Guangqiang; Xiong, Zhiqiang; Zhang, Hui; Song, Xin; Ai, Lianzhong; Xia, Yongjun
• Is Part Of: Food & function. Volume 12:Issue 7(2021)
• Page Start: 2925
• Page End: 2937
• Publication Date: 2021-03-15
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/d0fo03345f
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : In this study, we investigated the hepatoprotective effects of AdA and the underlying mechanism at the liver metabolomics and gut microbiota levels under alcohol-induced liver injury conditions. Abstract : This study aimed to investigate the protective effect of Antrodin A (AdA) from Antrodia camphorata ( A. camphorata ) mycelium on alcohol-induced gut microbiota and liver metabolomic disorders. In acute alcoholic liver injury mice, AdA ameliorated alcoholic exposure-induced hepatic lipid deposition (TC and TG), oxidative stress (MDA), inflammation (TNF-α, IL-1β, IL-6, IL-17 and IFN-γ), and liver damage via modulating microbiome and metabolomic responses. AdA restored the composition of intestinal flora with an increase in the relative abundance of Lactobacillus and Dubosiella and a decrease in Clostridium_sensu_stricto_1, Lachnospiraceae_NK4A136_group, Prevotellaceae_NK3B31_group, and Prevotellaceae_UCG-001 . Besides, AdA favorably regulated alcohol-induced metabolic disorders, including glutathione metabolism ( S -(2-hydroxyethyl)glutathione and glutathione oxidized), ascorbate and aldarate metabolism (l -ascorbic acid), and taurine and hypotaurine metabolism (taurine). In conclusion, AdA in A. camphorata is a beneficial active ingredient to treat the microbiomic and metabolic disturbance induced by alcohol intake.