Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus. (1st January 2021)

• Record Type: Journal Article
• Authors: Ryu, Se Hwan; Hong, Seong Min; Khan, Zahra; Lee, Seul Ki; Vishwanath, Manjunatha; Turk, Ayman; Yeon, Sang Won; Jo, Yang Hee; Lee, Dae Hee; Lee, Jae Kang; Hwang, Bang Yeon; Jung, Jae-Kyung; Kim, Sun Yeou; Lee, Mi Kyeong
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 31(2021)
• Publication Date: 2021-01-01
• Subjects: Hericium erinaceus -- Hericiaceae -- Isoindolinone -- Neurotrophic factor -- Neurite outgrowth -- Isohericerinol A; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2020.127714
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Four compounds, hericerin (1 ), isohericerinol A (2 ), N -de-phenylethyl isohericerin (3 ) and corallocin A (4 ) were isolated from the fruiting bodies of Hericium erinaceus, a lion's mane mushroom (Hericiaceae). Among them, isohericerinol A (2 ) was newly reported in nature. Further investigation of the neurotrophic effect of isolated compounds demonstrated that isohericerinol A (2 ) strongly increased the nerve growth factor (NGF) production in C6 glioma cells followed by corallocin A (4 ) and hericerin (1 ). Increased NGF production by these compounds promoted the neurite outgrowth in N2a neuronal cells. Western blot analysis also showed the increased protein expression of NGF, brain-derived neurotrophic factor (BDNF) and synaptophysin (SYP) in C6-N2a cells. Taken together, our present study characterized the neurotrophic constituents of H. erinaceus, which may support the potential use of memory improvement.