Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus. (1st January 2021) - Ryu, Se Hwan
Graphical abstract: Abstract: Four compounds, hericerin (1 ), isohericerinol A (2 ), N -de-phenylethyl isohericerin (3 ) and corallocin A (4 ) were isolated from the fruiting bodies of Hericium erinaceus, a lion's mane mushroom (Hericiaceae). Among them, isohericerinol A (2 ) was newly reported in nature. Further investigation of the neurotrophic effect of isolated compounds demonstrated that isohericerinol A (2 ) strongly increased the nerve growth factor (NGF) production in C6 glioma cells followed by corallocin A (4 ) and hericerin (1 ). Increased NGF production by these compounds promoted the neurite outgrowth in N2a neuronal cells. Western blot analysis also showed the increased protein expression of NGF, brain-derived neurotrophic factor (BDNF) and synaptophysin (SYP) in C6-N2a cells. Taken together, our present study characterized the neurotrophic constituents of H. erinaceus, which may support the potential use of memory improvement.