Blocking the Enablers: Selective Inhibition of CDK9 Reins in an Unchecked Master Regulator. Issue 2 (18th February 2021)

• Record Type: Journal Article
• Authors: Ansari, Aseem Z.
• Is Part Of: Cell chemical biology. Volume 28:Issue 2(2021)
• Page Start: 113
• Page End: 115
• Publication Date: 2021-02-18
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2021.01.022
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : In their quest to disable androgen receptor variants that drive castration-resistant prostate cancer, Richters et al. (2020) have hit upon a selective inhibitor of a transcriptional kinase that enables full-length mRNA synthesis. Drugging this essential kinase curbs tumor growth, thus making it an attractive focal target for transcription therapy. Abstract : In their quest to disable androgen receptor variants that drive castration-resistant prostate cancer, Richters et al. have hit upon a selective inhibitor of a transcriptional kinase that enables full-length mRNA synthesis. Drugging this essential kinase curbs tumor growth, thus making it an attractive focal target for transcription therapy.