Blocking the Enablers: Selective Inhibition of CDK9 Reins in an Unchecked Master Regulator. Issue 2 (18th February 2021) - Ansari, Aseem Z.
Abstract : In their quest to disable androgen receptor variants that drive castration-resistant prostate cancer, Richters et al. (2020) have hit upon a selective inhibitor of a transcriptional kinase that enables full-length mRNA synthesis. Drugging this essential kinase curbs tumor growth, thus making it an attractive focal target for transcription therapy. Abstract : In their quest to disable androgen receptor variants that drive castration-resistant prostate cancer, Richters et al. have hit upon a selective inhibitor of a transcriptional kinase that enables full-length mRNA synthesis. Drugging this essential kinase curbs tumor growth, thus making it an attractive focal target for transcription therapy.