Advances in the preparation and assessment of the biological activities of chitosan oligosaccharides with different structural characteristics. Issue 3 (12th January 2021)

• Record Type: Journal Article
• Authors: Zhou, Jingwen; Wen, Bingjian; Xie, Hongyi; Zhang, Chengcheng; Bai, Yan; Cao, Hua; Che, Qishi; Guo, Jiao; Su, Zhengquan
• Is Part Of: Food & function. Volume 12:Issue 3(2021)
• Page Start: 926
• Page End: 951
• Publication Date: 2021-01-12
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/d0fo02768e
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : The bioactivity of chitosan oligosaccharides (COSs) is closely related to the amino groups, acetyl groups, hydroxyl groups and degree of polymerization of their molecular structure, and to their molecular weight. Abstract : Chitosan oligosaccharides (COSs) are widely used biopolymers that have been studied in relation to a variety of abnormal biological activities in the food and biomedical fields. Since different COS preparation technologies produce COS compounds with different structural characteristics, it has not yet been possible to determine whether one or more chito-oligomers are primarily responsible for the bioactivity of COSs. The inherent biocompatibility, mucosal adhesion and nontoxic nature of COSs are well documented, as is the fact that they are readily absorbed from the intestinal tract, but their structure–activity relationship requires further investigation. This review summarizes the methods used for COS preparation, and the research findings with regard to the antioxidant, anti-inflammatory, anti-obesity, bacteriostatic and antitumour activity of COSs with different structural characteristics. The correlation between the molecular structure and bioactivities of COSs is described, and new insights into their structure–activity relationship are provided.