Distinct Antiviral Properties of Two Different Bacterial Lysates. (4th February 2021)

• Record Type: Journal Article
• Authors: Roth, Michael; Khameneh, Hanif J.; Fang, Lei; Tamm, Michael; Rossi, Giovanni A.
• Other Names: Zhu Youfeng Academic Editor.
• Is Part Of: Canadian respiratory journal. Volume 2021(2021)
• Publication Date: 2021-02-04
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Canada -- Periodicals; Respiration; Respiratory organs -- Diseases; Canada; Respiratory Tract Diseases -- Periodicals; Periodicals; Periodicals; 616.2
• DOI: 10.1155/2021/8826645
• Languages: English
• ISSNs: 1198-2241

Abstract

Abstract : Oral bacterial lysates (OBLs) can reduce the frequency and severity of recurrent respiratory tract infections in children from viral and bacterial origins. OBL-induced early innate immune reaction was already shown, but the specific features of different OBLs have never been studied and compared. A study was conducted to assess in vitro the protective effects on rhinovirus- (RV-) infected human bronchial epithelial cells (BECs) of two slightly different OBLs: OM-85 and Pulmonarom. Furthermore, since immune cells represent the key arm for antiviral defence, the capacity of these OBLs to induce selected cytokine production in mouse bone marrow-derived DCs (BMDCs) was also evaluated. Although different OBLs may share some mechanisms to protect host cells from virus infection, some product-specific antimicrobial activities were observed on RV-infected human BECs and mouse BMDCs. These results are consistent with a product-specific response possibly triggered by different pathogen-associated molecular patterns (PAMPs) contained in OBLs.