Metabolomic Changes after Coffee Consumption: New Paths on the Block. Issue 3 (28th December 2020)

• Record Type: Journal Article
• Authors: Favari, Claudia; Righetti, Laura; Tassotti, Michele; Gethings, Lee Andrew; Martini, Daniela; Rosi, Alice; Antonini, Monica; Rubert, Josep; Manach, Claudine; Dei Cas, Alessandra; Bonadonna, Riccardo; Brighenti, Furio; Dall'Asta, Chiara; Mena, Pedro; Del Rio, Daniele
• Is Part Of: Molecular nutrition & food research. Volume 65:Issue 3(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-28
• Subjects: biomarker -- cocoa -- coffee -- metabolomics -- xenobiotics; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.202000875
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aims at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups of espresso coffee/day, and one cup of espresso coffee/day and two cocoa‐based products containing coffee two times per day) may impact endogenous molecular pathways. Methods and Results: A three‐arm, randomized, crossover trial is performed in 21 healthy volunteers who consumed each treatment for one month. Urine samples are collected to perform untargeted metabolomics based on UHPLC‐IMS‐HRMS. A total of 153 discriminant metabolites are identified. Several molecular features are associated with coffee consumption, while others are linked with different metabolic pathways, such as phenylalanine, tyrosine, energy metabolism, steroid hormone biosynthesis, and arginine biosynthesis and metabolism. Conclusion: This information has provided new insights into the metabolic routes by which coffee and coffee‐related metabolites may exert effects on human health. Abstract : It has been demonstrated how untargeted metabolomics may disclose not only the fate of coffee components after ingestion, but also how coffee can modulate endogenous metabolome changes. Besides identifying biomarkers of intake, endogenous metabolites from the phenylalanine, tyrosine, arginine biosynthesis and metabolism, energy metabolism, and steroid hormone biosynthesis are shown to be regulated by different patterns of coffee intake, which may shed light on the preventive effects of coffee.