Analysis of [11C]Choline and [13N]Ammonia using a single HPIC method. (February 2021)

• Record Type: Journal Article
• Authors: Jiang, Huailei; Fang, Ping; Jacobson, Mark S.; Jain, Manoj K.; Cai, Hancheng
• Is Part Of: Applied radiation and isotopes. Volume 168(2021)
• Publication Date: 2021-02
• Subjects: PET -- [11C]Choline -- [13N]Ammonia -- Quality control -- HPIC -- Method validation; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2020.109560
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: A single HPIC method was developed and validated for the analysis of both [ 11 C]Choline and [ 13 N]Ammonia with the same setup. The HPIC system suitability tests were performed and [ 11 C]Choline and [ 13 N]Ammonia were used to verify their performance on this HPIC method. The HPIC setup and method provides qualitative and quantitative analysis information of [ 11 C]Choline and [ 13 N]Ammonia. The data suggested this HPIC method is validated for determining radiochemical/chemical purity and radiochemical identity of [ 11 C]Choline and [ 13 N]Ammonia products in CGMP compliant manufacturing process. Highlights: High pressure ion chromatography (HPIC) method was developed for PET drug analysis. A single HPIC method for both [ 11 C]Choline and [ 13 N]Ammonia analysis. HPIC can serve as a powerful tool for the analysis of diverse radiopharmaceuticals.