Analysis of [11C]Choline and [13N]Ammonia using a single HPIC method. (February 2021) - Jiang, Huailei
Abstract: A single HPIC method was developed and validated for the analysis of both [ 11 C]Choline and [ 13 N]Ammonia with the same setup. The HPIC system suitability tests were performed and [ 11 C]Choline and [ 13 N]Ammonia were used to verify their performance on this HPIC method. The HPIC setup and method provides qualitative and quantitative analysis information of [ 11 C]Choline and [ 13 N]Ammonia. The data suggested this HPIC method is validated for determining radiochemical/chemical purity and radiochemical identity of [ 11 C]Choline and [ 13 N]Ammonia products in CGMP compliant manufacturing process. Highlights: High pressure ion chromatography (HPIC) method was developed for PET drug analysis. A single HPIC method for both [ 11 C]Choline and [ 13 N]Ammonia analysis. HPIC can serve as a powerful tool for the analysis of diverse radiopharmaceuticals.