Nanoresistant Particles Based on Chemically Modified Starch as Nanocarriers and Characterization of Structural and Release Properties. (27th October 2020)

• Record Type: Journal Article
• Authors: Ouyang, Qunfu; Xiao, Jiaqi; Chen, Jialin; Xiao, Yiwei; Lin, Qinlu; Ding, Yongbo
• Is Part Of: Stärke. Volume 73:Number 1/2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-27
• Subjects: emulsification–physical technique -- in vitro digestibility -- in vitro release properties -- nanoresistant starch particles -- stability; Starch -- Periodicals; 572.566
• DOI: 10.1002/star.201900317
• Languages: English
• ISSNs: 0038-9056

Abstract

Abstract: Nanoresistant particles based on chemically modified starch (RS IV) are prepared through a high‐speed shearing emulsification method, and the effects of shear speed, shear time, oil/water ratio, and surfactant amount on the particle size are evaluated in this study. The as‐prepared RS IV nanoparticles yield ≈300 nm narrow peak with notches and grooves on the surface. In vitro digestibility results suggest that these nanoparticles exhibit high resistance in the stomach, small intestine, and colon contents of mice. A raman assay confirms that a crosslinking reaction occurs between the RSIV molecule and N, N ′‐methylenediacrylamide. X‐ray diffraction (XRD) and differential scanning calorimetry (DSC) reveal that RS IV nanoparticles present an amorphous structure. In addition, the RS IV nanoparticles have good thermal and storage stabilities. In comparison with RS IV, RS IV nanoparticles have a larger specific surface area, smaller average pore size, higher loading capacity and encapsulation efficiency, and better in vitro release properties of drugs. Abstract : RS IV nanoparticles are successfully synthesized via high‐speed shearing emulsification. In vitro studies show that they demonstrate high resistance in the stomach, small intestine, and colon contents of mice. Moreover, these nanoparticles have adsorption properties and long in vitro release properties, which can be used as a wall material for colon‐specific controlled release delivery systems.