Highly selective recognition of intramolecular parallel G-quadruplex using a chiral supramolecular probe. (February 2021)

• Record Type: Journal Article
• Authors: Wang, Li-Xia; Zhang, Jing-Tao; Sun, Xin; Yang, Da-Wei; Tang, Ya-Lin
• Is Part Of: Dyes and pigments. Volume 185(2021)Part A
• Publication Date: 2021-02
• Subjects: Chiral supramolecule probe -- Molecular recognition -- DNA G-quadruplex -- Self-assembly -- Lighting-up probe; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2020.108882
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Owing to their chiral and self-assembly features, chiral supramolecules exhibit superior recognition and catalytic abilities. Here, we construct a chiral H-aggregates based on a cyanine dye, 3, 3′-di(3-sulfopropyl)-4, 5, 4′5′-dibenzo-9-methyl-thiacarbocyanine triethylammonium salt (MeCy), by spontaneous symmetry breaking in the presence of NaNO3 . The chiral H-aggregates could specially recognize parallel DNA G-quadruplexes among other DNA types, probably by a three-step process, which comprises the amplified chiral induction, the disassembly of chiral H-aggregates and the binding of the MeCy monomer. The MeCy monomer binding to DNA parallel G-quadruplex led to a lighting-up fluorescence intensity obviously. Chiral supramolecules targeted to DNA G-quadruplex was proposed, and its transformation process was revealed, and thus potentially provided an excellent probe for DNA parallel G-quadruplexes. Graphical abstract: To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Image 1 Highlights: A chiral supramolecular probe targeting to DNA G-quadurplex was proposed. The chiral H-aggregates could specially recognize parallel DNA G-quadruplexes among other DNA types. Chiral H-aggregates could disassociate into its monomer by a lighting-up protocol interacting with parallel G-quadruplexes.