Highly selective recognition of intramolecular parallel G-quadruplex using a chiral supramolecular probe. (February 2021) - Wang, Li-Xia
Abstract: Owing to their chiral and self-assembly features, chiral supramolecules exhibit superior recognition and catalytic abilities. Here, we construct a chiral H-aggregates based on a cyanine dye, 3, 3′-di(3-sulfopropyl)-4, 5, 4′5′-dibenzo-9-methyl-thiacarbocyanine triethylammonium salt (MeCy), by spontaneous symmetry breaking in the presence of NaNO3 . The chiral H-aggregates could specially recognize parallel DNA G-quadruplexes among other DNA types, probably by a three-step process, which comprises the amplified chiral induction, the disassembly of chiral H-aggregates and the binding of the MeCy monomer. The MeCy monomer binding to DNA parallel G-quadruplex led to a lighting-up fluorescence intensity obviously. Chiral supramolecules targeted to DNA G-quadruplex was proposed, and its transformation process was revealed, and thus potentially provided an excellent probe for DNA parallel G-quadruplexes. Graphical abstract: To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Image 1 Highlights: A chiral supramolecular probe targeting to DNA G-quadurplex was proposed. The chiral H-aggregates could specially recognize parallel DNA G-quadruplexes among other DNA types. Chiral H-aggregates could disassociate into its monomer by a lighting-up protocol interacting with parallel G-quadruplexes.