Insights from in vitro exploration of factors influencing iron, zinc and provitamin A carotenoid bioaccessibility and intestinal absorption from cereals. (November 2020)

• Record Type: Journal Article
• Authors: Ferruzzi, Mario G.; Kruger, Johanita; Mohamedshah, Zulfiqar; Debelo, Hawi; Taylor, John R.N.
• Is Part Of: Journal of cereal science. Volume 96(2020)
• Publication Date: 2020-11
• Subjects: Cereals -- Iron -- Zinc -- Provitamin A carotenoids -- Bioaccessibility -- In vitro methods; Grain -- Periodicals; Cereal products -- Periodicals; Céréales -- Périodiques; Produits céréaliers -- Périodiques; Cereal products; Grain; Periodicals; 664.705
• DOI: 10.1016/j.jcs.2020.103126
• Languages: English
• ISSNs: 0733-5210

Abstract

Abstract: Developments in genetics, agronomics and processing has positioned staple cereals as important sources of iron, zinc and provitamin A (pVA) carotenoids for nutritionally vulnerable populations . Significant effort has been placed on understanding the bioavailability of these micronutrients from cereal foods, including the exploration of underlying mechanisms by which their bioavailability can be modified. While micronutrient bioavailability is preferably assessed in clinical trials, relevant in vitro digestion and intestinal cell culture models have been applied to study effects of genetic, agronomic, post-harvest and food processing on micronutrient bioavailability. This review (1) critically assesses the application of in vitro models in the exploration of mechanisms associated with iron, zinc and provitamin A carotenoid bioaccessibility and intestinal absorption from cereal foods, and (2) identifies remaining gaps in order to frame future strategies to improve the nutritional impact of cereal foods. Graphical abstract: Image 1 Highlights: In vitro model are useful in the study of Fe, Zn and pVA bioavailability from cereal foods. In vitro studies suggest interactions with inhibitors/promotors as bioaccessibility modifiers. Bioaccessibility and intestinal uptake may be impacted by cereal matrix/processing independently. Impacts to intestinal transport mechanisms from whole cereal foods remain to be studied in detail.