Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV. (24th May 2019)

• Record Type: Journal Article
• Authors: Teeraananchai, Sirinya; Kerr, Stephen J; Gandhi, Monica; Do, Viet Chau; Van Nguyen, Lam; Tran, Dan Ngoc Hanh; Kosalaraksa, Pope; Singtoroj, Thida; Thammajaruk, Narukjaporn; Jupimai, Thidarat; Sohn, Annette H
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 9:Number 2(2020)
• Page Start: 253
• Page End: 256
• Publication Date: 2019-05-24
• Subjects: adherence -- hair concentration -- HIV -- second-line ART -- virologic failure -- virologic resuppression; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piz034
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: Of 56 children with perinatally acquired human immunodeficiency virus (HIV) who had been prescribed second-line protease inhibitor–based antiretroviral therapy and had ≥1 previous episode of viral failure (HIV RNA, ≥1000 copies/mL), 46% had ≥1, 34% had ≥2, and 23% had ≥3 consecutive episodes of viral failure during the 2 years of follow-up. Two of these children experienced a major protease inhibitor mutation. Abstract : Asian children and adolescents with persistent human immunodeficiency virus viremia who had been prescribed a second-line treatment regimen were often found by objective measures to not be taking their medicine at all. These youth are at serious risk of treatment failure and acquired immunodeficiency syndrome.