Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV. (24th May 2019) - Teeraananchai, Sirinya
Abstract: Of 56 children with perinatally acquired human immunodeficiency virus (HIV) who had been prescribed second-line protease inhibitor–based antiretroviral therapy and had ≥1 previous episode of viral failure (HIV RNA, ≥1000 copies/mL), 46% had ≥1, 34% had ≥2, and 23% had ≥3 consecutive episodes of viral failure during the 2 years of follow-up. Two of these children experienced a major protease inhibitor mutation. Abstract : Asian children and adolescents with persistent human immunodeficiency virus viremia who had been prescribed a second-line treatment regimen were often found by objective measures to not be taking their medicine at all. These youth are at serious risk of treatment failure and acquired immunodeficiency syndrome.