Cumulative soft drink consumption is associated with insulin resistance in Mexican adults. Issue 3 (29th June 2020)

• Record Type: Journal Article
• Authors: Rivera-Paredez, Berenice; Torres-Ibarra, Leticia; González-Morales, Romina; Barrientos-Gutiérrez, Tonatiuh; Hernández-López, Rubí; Ramírez, Paula; León-Maldonado, Leith; Velázquez-Cruz, Rafael; Denova-Gutiérrez, Edgar; Salmerón, Jorge
• Is Part Of: American journal of clinical nutrition. Volume 112:Issue 3(2020)
• Page Start: 661
• Page End: 668
• Publication Date: 2020-06-29
• Subjects: soft drink -- homeostasis model assessment -- insulin resistance -- Mexican adults -- Health Workers Cohort Study; Diet therapy -- Periodicals; Nutrition -- Periodicals; Dietetics -- Periodicals; 613.205
• DOI: 10.1093/ajcn/nqaa169
• Languages: English
• ISSNs: 0002-9165

Abstract

ABSTRACT: Background: Insulin resistance (IR) is an important risk factor for type 2 diabetes (T2D) and other cardiometabolic diseases. Recent studies suggest that soft drink consumption could increase IR. However, inconsistent findings have been observed. Objective: The aim was to estimate the association between the cumulative consumption of soft drinks and IR by means of the HOMA-IR in Mexican adults. Methods: We analyzed the association between cumulative consumption of soft drinks and HOMA-IR change after 7 y of follow-up in participants ( n = 1073) of the Health Workers Cohort Study. Soft drink consumption was estimated by food-frequency questionnaires. Insulin was measured by chemiluminescence, and fasting glucose was measured with the enzymatic colorimetric method. HOMA-IR was computed as fasting insulin (mIU/L) × fasting glucose (mmol/L)/22.5. To assess the relation between cumulative soft drink consumption and HOMA-IR change, we performed robust linear regression models. Additionally, we used fixed-effects models to estimate the association between changes in soft drink consumption and change in HOMA-IR. Results: At baseline, the average age was 44 y. Mean cumulative soft drink consumption was 0.42 servings/d. Median HOMA-IR increased from 1.5 at baseline to 2.0 at follow-up. Soft drink consumption was positively associated with HOMA-IR change. In the multiple linear regression analysis, for each increase in the consumption of 2 (355 mL) soft drinks/d, the average change between baseline and follow-up HOMA-IR showed an increase of 1.11 units (95% CI: 0.74, 1.48). Conclusions: Our data support the hypothesis that, in Mexican adults, a higher soft drink consumption is associated with an increase in HOMA-IR, despite known risk factors. These findings support the need for reinforcing policies to reduce soft drink consumption in our population.