Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice. (15th March 2021)

• Record Type: Journal Article
• Authors: Donado-Pestana, Carlos M.; Pessoa, Érika V.M.; Rodrigues, Larissa; Rossi, Rafaela; Moura, Márcio H.C.; dos Santos-Donado, Priscila R.; Castro, Érique; Festuccia, William T.; Genovese, Maria Inés
• Is Part Of: Food chemistry. Volume 340(2021)
• Publication Date: 2021-03-15
• Subjects: Phenolic compounds -- Cambucizeiro -- Myrtaceae -- Obesity -- Inflammation; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2020.128169
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Cambuci polyphenol extract (CBC) was evaluated in a therapeutic model of obesity. CBC improved glucose homeostasis and decreased body weight gain in obese mice. CBC ameliorated insulin resistance in liver and muscle and hepatic steatosis. CBC attenuated obesity-associated inflammation in liver and muscle tissues. Abstract: Polyphenols from cambuci (CBC) ( Campomanesia phaea (O. Berg.)), a Brazilian native fruit, were investigated on therapeutic actions mitigating insulin resistance and hepatic steatosis in high-fat-sucrose diet (HFS) induced obese mice. For this, C57BL/6J mice fed with a obesogenic and diabetogenic HFS diet were administered with either water or two CBC doses (36 or 74 mg gallic acid equivalent (GAE)/kg body weight) by gavage from week 6 to week 14 (end-point) of HFS feeding. CBC reduced body weight gain, inflammation, hepatic steatosis, hyperglycemia, glucose intolerance, and insulin resistance in liver and skeletal muscle of obese mice, and such effects were associated with activation of Akt and AMPK in these tissues. In conclusion, polyphenols from CBC show important therapeutic actions ameliorating obesity-associated complications.